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Sporlac Qik

The term “probiotic” has been firstly defined by Fuller as “a live microbial feed supplement which beneficially affects the host by improving its intestinal microbial balance”.his definition has been extended to health and  probiotics were redefined as “live micro-organisms that, when administered in adequate amounts, confer a health benefit to the host”.The intestine contains a complex and dynamic microflora  including more than 2000 micro-organism species coexisting  in a complex equilibrium with the host. This microflora has various effects including metabolic activities, trophic effects on the intestinal epithelium, interactions with the host immune system and acts as a barrier to prevent colonization by opportunistic and pathogenic micro-organisms. The immune system and particularly the gut-associated lymphoid tissues provides the host with protective mechanisms against pathogen invasion across the intestinal mucosal surface. However, disequilibrium in the gut microflora ecology and in the immune response could induce gastrointestinal diseases.

Saccharomyces boulardii, isolated from litchi fruit by Henri Boulard in the 1920s, belongs to the Saccharomyces genus which is commonly used in several food processes including beverages and bred fermentation. This yeast is frequently prescribed in a lyophilized form as a biotherapeutic agent.Controlled clinical trials have shown that oral administration of S. boulardii could treat or prevent gastrointestinal diseases such as antibiotic-associated diarrhoea , recurrent Clostridium difficile-associated diseases, traveller’s diarrhoea, children acute diarrhoea , enteral tube acute diarrhoea in children,enteral tube feeding-associated diarrhoea , AIDS associated diarrhoea  intestinal bowel disease such as Crohn’s disease and ulcerative colitis and irritable bowel syndrome.

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