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Elle Metchinkoff, a Zoologist, Biologist had a number of other credentials and won a Noble prize for his pioneering  contribution on phagocytes.However his greatest contribution, is proposing a theory that gut bacteria that are capable of producing Lactic acid prolong life. How true he was that today a number of beneficial microbes known as probiotics, are being used to treat both acute and chronic diosrders. Probiotics, also play a vital role, in a number of biochemical processes in the human body and also playing a role in immunostimulation. The use of probiotics, in treating various conditions, is the field of bio-therapeutics. [Synthesis of essential vitamins, absorption of minerals and trace elements, improving defence mechanisms of the body etc. that are important for maintaining good health]

Zinc is known to play a central role in the immune system, and zinc-deficient persons experience increased susceptibility to a variety of pathogens. The immunologic mechanisms whereby zinc modulates increased susceptibility to infection have been studied for several decades. It is clear that zinc affects multiple aspects of the immune system, from the barrier of the skin to gene regulation within lymphocytes. Zinc is crucial for normal development and function of cells mediating nonspecific immunity such as neutrophils and natural killer cells. Zinc deficiency also affects development of acquired immunity by preventing both the outgrowth and certain functions of T lymphocytes such as activation, Th1 cytokine production, and B lymphocyte help. Likewise, B lymphocyte development and antibody production, particularly immunoglobulin G, is compromised. The macrophage, a pivotal cell in many immunologic functions, is adversely affected by zinc deficiency, which cans dysregulate intracellular killing, cytokine production, and phagocytosis. The effects of zinc on these key immunologic mediators is rooted in the myriad roles for zinc in basic cellular functions such as DNA replication, RNA transcription, cell division, and cell activation. Apoptosis is potentiated by zinc deficiency. Zinc also functions as an antioxidant and can stabilize membranes.

Bacillus coagulans, maintains a symbiotic relationship, with the humans and plays a vital role in maintaining the gut flora, the metabolic secretions, such as bacetriocins, lactic acid plays a vital role in the  controlling the growth of unwanted pathogens, and supporting the growth of Bifidobacterium in the colon, maintining the membrane integrity of the gut. In addition to these functions, the microbial organism also maintains the intestinal immunity, not allowing the passage of pathogens across the intestinal barrier. The vital function played by B.coagulans, is the synthesis of vitamins especially the B-complex and also the absorption of minerals, vitamins and trace elements in normal states and states of altered function such as viral, bacterial or other states of altered immunity.

Thus a combination of  Zinc + Bacillus coagulans, plays a vital role in altered states of immunity, both in the adult and paediatric group, helping the body restore the normal physiological function.In addition, to immunity, the combination, is being used by Physicians in diarrhoea of varied aetiology as Zinc has been recommended by the WHO as an important trace element for quickcontrol of diarrhoea. The combination can be safely used along with ORS.

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